Radiation therapy management in BRCA1/2 carriers diagnosed with early breast cancer: An international cohort study

C Becherini; E Blondeaux; V Delucchi; L Visani; HJ Kim; F Coussy; R Bernstein-Molho; A Di Meglio; FS Hilbers; K Pogoda; A Kwong; E Agostinetto; A Baten; J Bajpai; J Balmana; HCF Moore; AH Partridge; C Rousset-Jablonski; KA Phillips; A Toss; T Renaud; A Ferrari; FA Peccatori; L Sanchez; S Paluch-Shimon; W Cui; SM Wong; JM Ryu; R Fruscio; MK Lee; C Vernieri; A Matikas; FJ Couch; L De Marchis; MV Dieci; D Aguilar-Y-Mendez; SE Hwang; M Rozenblit; D Can Güven; B Mrinakova; N Harbeck; R Sanchez-Bayona; L Boni; M Lambertini; I Meattini

Journal article

Radiation therapy management in BRCA1/2 carriers diagnosed with early breast cancer: An international cohort study

C Becherini, E Blondeaux, V Delucchi, L Visani, HJ Kim, F Coussy, R Bernstein-Molho, A Di Meglio, FS Hilbers, K Pogoda, A Kwong, E Agostinetto, A Baten, J Bajpai, J Balmana, HCF Moore, AH Partridge, C Rousset-Jablonski, KA Phillips, A Toss Show all

Radiotherapy and Oncology | Published : 2026

DOI: 10.1016/j.radonc.2026.111523

Abstract

Background: The oncological safety of breast-conserving surgery followed by radiation therapy (BCS + RT) in young women carrying pathogenic or likely pathogenic BRCA1/2 variants remains debated, with mastectomy (MS) often favoured despite limited comparative real-world evidence. We evaluated survival and recurrence outcomes associated with different loco-regional strategies in a large international cohort of young BRCA carriers. Methods: The BRCA BCY Collaboration (NCT03673306) is a retrospective, multicentre cohort including women aged ≤ 40 years with invasive breast cancer and confirmed germline BRCA1/2 variants treated between 2000 and 2020. Outcomes were compared between patients treated..

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